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| Monday, September 29th , 2025 |
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| Purchased the contract of RP Sean Boyle from Triple A Toledo. |
| Purchased the contract of LF Nathan Lukes from Triple A Toledo. |
| Wednesday, July 9th , 2025 |
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| Placed CF Tyler Freeman on the active roster. |
| Activated CF Tyler Freeman from the injured list. |
| Placed SP Adrian Houser on the active roster. |
| Activated SP Adrian Houser from the injured list. |
| Tuesday, July 1st , 2025 |
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| Placed SP Charlie Morton on the 60-day injured list. |
| Saturday, June 14th , 2025 |
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| Placed RP Spencer Turnbull on the 60-day injured list. |
| Placed RP Trevor Williams on the active roster. |
| Placed SP Adrian Houser on the 15-day injured list, retroactive to 06/11/2025. |
| Placed SP Charlie Morton on the active roster. |
| Activated SP Charlie Morton from the injured list. |
| Wednesday, June 11th , 2025 |
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| Placed SP Charlie Morton on the 15-day injured list, retroactive to 06/10/2025. |
| Placed CF Tyler Freeman on the 10-day injured list, retroactive to 06/08/2025. |
| Friday, June 6th , 2025 |
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| RP Trevor Williams was designated for assignment and placed on waivers. |
| Placed RP Hector Neris on the active roster. |
| Friday, May 30th , 2025 |
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| RP Hector Neris was designated for assignment and placed on waivers. |
| Placed RP Trevor Williams on the active roster. |
| Thursday, May 22nd , 2025 |
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| RP Trevor Williams was designated for assignment and placed on waivers. |
| Placed RP Hector Neris on the active roster. |
| Wednesday, May 14th , 2025 |
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| Sent SP Charlie Morton to Triple A Toledo for injury rehab. |
| RP Hector Neris was designated for assignment and placed on waivers. |
| Placed RP Trevor Williams on the active roster. |
| Thursday, May 8th , 2025 |
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| RP Trevor Williams was designated for assignment and placed on waivers. |
| Placed 3B Miguel Sano on the active roster. |
| Wednesday, April 30th , 2025 |
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| 3B Miguel Sano was designated for assignment and placed on waivers. |
| Placed RP Trevor Williams on the active roster. |
| Tuesday, April 22nd , 2025 |
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| RP Trevor Williams was designated for assignment and placed on waivers. |
| Placed 3B Miguel Sano on the active roster. |
| Monday, April 14th , 2025 |
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| Placed SP Charlie Morton on the 15-day injured list, retroactive to 04/11/2025. |
| Placed RP Hector Neris on the active roster. |
| 3B Miguel Sano was designated for assignment and placed on waivers. |
| Placed C Elias Diaz on the active roster. |
| Wednesday, April 9th , 2025 |
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| C Elias Diaz was designated for assignment and placed on waivers. |
| Placed 3B Miguel Sano on the active roster. |
| Sunday, April 6th , 2025 |
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| RP Hector Neris was designated for assignment and placed on waivers. |
| Placed C Elias Diaz on the active roster. |
| Tuesday, April 1st , 2025 |
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| Placed RP Joe Ross on the 60-day injured list. |
| Placed 3B Miguel Sano on the active roster. |
| 3B Miguel Sano was designated for assignment and placed on waivers. |
| Placed C Elias Diaz on the active roster. |
| C Elias Diaz was designated for assignment and placed on waivers. |
| Placed RP Trevor Williams on the active roster. |
| Friday, March 21st , 2025 |
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| RP Trevor Williams was designated for assignment and placed on waivers. |
| Placed RP Hector Neris on the active roster. |
| Tuesday, March 18th , 2025 |
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| Demoted RF Jacob Melton to Triple A Toledo. |
| Optioned CF Hunter Bishop to Triple A Toledo. |
| Optioned CF Jimmy Herron to Triple A Toledo. |
| Demoted 3B Alex Freeland to Triple A Toledo. |
| Optioned 3B Joe Perez to Triple A Toledo. |
| Optioned 2B Nick Madrigal to Triple A Toledo. |
| Optioned 2B Braden Shewmake to Triple A Toledo. |
| Optioned 2B Lenyn Sosa to Triple A Toledo. |
| Demoted 1B Bryce Eldridge to Triple A Toledo. |
| Optioned C Cooper Johnson to Triple A Toledo. |
| Demoted RP T.J. Brock to Triple A Toledo. |
| Demoted RP Cameron Cotter to Triple A Toledo. |
| Optioned RP Jake Kalish to Triple A Toledo. |
| Demoted SP Cade Horton to Triple A Toledo. |
| Optioned SP Cade Cavalli to Triple A Toledo. |
| Optioned SP Sean Boyle to Triple A Toledo. |
| Optioned SP Osvaldo Bido to Triple A Toledo. |
| Optioned LF Nathan Lukes to Triple A Toledo. |
| 3B Miguel Sano was designated for assignment and placed on waivers. |
| C Elias Diaz was designated for assignment and placed on waivers. |
| Optioned SP Jake Irvin to Triple A Toledo. |
| Purchased the contract of 3B Alex Freeland from Triple A Toledo. |
| Friday, March 7th , 2025 |
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| RP Hector Neris was designated for assignment and placed on waivers. |
| Placed 3B Miguel Sano on the active roster. |
| Friday, February 21st , 2025 |
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| 3B Miguel Sano was designated for assignment and placed on waivers. |
| Placed RP Hector Neris on the active roster. |
| Thursday, February 20th , 2025 |
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| Invited non-roster RP Cameron Cotter to Spring Training camp. |
| Invited non-roster RP T.J. Brock to Spring Training camp. |
| Invited non-roster RF Jacob Melton to Spring Training camp. |
| Invited non-roster 3B Alex Freeland to Spring Training camp. |
| Invited non-roster SP Cade Horton to Spring Training camp. |
| Invited non-roster 1B Bryce Eldridge to Spring Training camp. |
| Tuesday, February 11th , 2025 |
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| Purchased the contract of SP Osvaldo Bido from Triple A Toledo. |
| Purchased the contract of CF Tyler Freeman from Triple A Toledo. |
| Purchased the contract of 2B Braden Shewmake from A West Michigan. |
| Purchased the contract of SS Santiago Espinal from Triple A Toledo. |
| Purchased the contract of 2B Nick Madrigal from Triple A Toledo. |
| Purchased the contract of SP Sean Boyle from Triple A Toledo. |
| Purchased the contract of CF Hunter Bishop from A West Michigan. |
| Purchased the contract of RP Jake Kalish from Triple A Toledo. |
| Purchased the contract of CF Jimmy Herron from Double A Erie. |
| Purchased the contract of SP Tobias Myers from Triple A Toledo. |
| Purchased the contract of RP Trevor Williams from Triple A Toledo. |
| Purchased the contract of 2B Lenyn Sosa from Double A Erie. |
| Purchased the contract of 3B Joe Perez from Double A Erie. |
| Purchased the contract of SP Cade Cavalli from Triple A Toledo. |
| Purchased the contract of C Cooper Johnson from Triple A Toledo. |
| Friday, February 7th , 2025 |
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| RP Hector Neris was designated for assignment and placed on waivers. |
| Placed 3B Miguel Sano on the active roster. |
| Optioned SP Osvaldo Bido to Triple A Toledo. |
| Wednesday, January 29th , 2025 |
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| 3B Miguel Sano was designated for assignment and placed on waivers. |
| Placed 1B Jurickson Profar on the active roster. |
| Tuesday, January 28th , 2025 |
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| Signed free agent 1B Jurickson Profar to a 3-year contract worth a total of $25,500,000. |
| Friday, January 24th , 2025 |
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| Placed SP Adrian Houser on the active roster. |
| Saturday, January 11th , 2025 |
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| Signed free agent SP Adrian Houser to a 3-year contract worth a total of $12,200,000. |
| Thursday, January 2nd , 2025 |
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| Assigned RP Dylan Coleman to Triple A Toledo. |
| Placed RP Wei-Chieh Huang on the active roster. |
| Placed RP Hector Neris on the active roster. |
